Isopropanol (IPA, CAS No 67-63-0) has been widely used as an industrial solvent and is a component of industrial and consumer products.
HERA applications include laundry detergents, hand dishwashing liquids and various hard surface cleaners.
The HERA risk assessment has shown that the use of IPA in HERA applications results in environmental risk characterization ratios less than one, indicating no concern, for all environmental compartments.
For human health, a margin of exposure of about 3800 has been calculated for the total aggregate consumer exposure. This MOE has been considered very large, large enough to account for the inherent uncertainty and variability of the database and inter and intra-species extrapolations, which have been considered by an assessment factor of 100 or greater. It can be concluded that the use of Isopropanol in household cleaning products raises no safety concern for consumers.
The outcome of this HERA risk assessment focussing on the specific uses of IPA in household cleaning detergents is fully consistent with that of the OECD HPV review which looked at all global uses of IPA. The SIDS initial assessment profile (SIAP) concluded that IPA has been considered of low priority for further work and poses no concern for the environment or human health.